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Workshop on data collection and structure solving in macromolecular X-ray diffraction.


Application deadline: 7th June 2019

It is our pleasure to invite you to 5-day long workshop on protein crystallography organized by Jerzy Haber Institute of Catalysis and Surface Chemistry PAS and Faculty of Chemistry, Jagiellonian University, that will take place on 12-16 July 2019 in Kraków. The workshop, which will consist of lectures and hands-on sessions, is dedicated to PhD and undergraduate students as well as research staff interested in protein X-ray diffraction methods. During a poster session the attendees will have a chance to present and discuss their own results. Number of places is limited to 40 in total. 

The lecture and hands-on topics included:

  • Crystallographic Fundamentals
  • Preparation of protein sample for crystallization experiments  (Expression, Purification and Validation)
  • Crystallization
  • Cryo-crystallography: preparation of crystals for data collection at cryogenic temperatures
  • Handling of crystals
  • X-ray sources, synchrotrons, detectors
  • Radiation damage
  • Indexing, integration and data reduction
  • Diffraction data quality
  • SAD/MAD/MR data collection (remote data collection in Argonne)
  • Data processing using XDS and XDSAPP
  • Molecular replacement
  • Isomorphous replacement and anomalous signal in solving the phase problem
  • Data processing with HKL
  • Data processing using XDS and XDSAPP
  • MR and SAD phasing and model building with HKL3000
  • Electron density map interpretation and model building
  • Structure refinement and validation
  • Structure refinement with Refmac / Coot
  • Macromolecular refinement at high resolution
  • Difficult structures - how to solve and refine
  • Interpretation of structural data
  • Capabilities of Structural Biology Core Facility at MCB Jagiellonian University in Kraków
  • Large Molecular complex - at the interface between X-ray and Cryo-EM
  • Protein crystallography in drug development
  • Impact of Reproducibility and Artificial Intelligence on Structure Based Drug Discovery
  • Share your story – presenting structural data on the Web

The lecturers and tutors (in alphabetical order):


For PhD candidates from outside Poland there are stipends available from the PROM programme to cover fee, travel and stay costs. More information on this is available here.


Registration form is available here. 

All correspondence concerning the workshop shall be sent to: prot.xrd(at)ikifp.edu.pl

Workshop is sponsored by Polish Academy of Sciences

Workshop is sponsored by: Polish Academy of Sciences, Lab Empire, Protomnis, Dectris 

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